Paradoxically, the tumor harbored an activating MAPK1 E322K mutation (allelic fraction 0.13), which predicts ERK activation and erlotinib resistance in EGFR-mutant lung cancer.
Paradoxically, the tumor harbored an activating MAPK1 E322K mutation (allelic fraction 0.13), which predicts ERK activation and erlotinib resistance in EGFR-mutant lung cancer.
Paradoxically, the tumor harbored an activating MAPK1 E322K mutation (allelic fraction 0.13), which predicts ERK activation and erlotinib resistance in EGFR-mutant lung cancer.
Paradoxically, the tumor harbored an activating MAPK1 E322K mutation (allelic fraction 0.13), which predicts ERK activation and erlotinib resistance in EGFR-mutant lung cancer.
The genetic mutations within MAPK1 (rs6928, rs9340, rs11913721), HIF-1 (rs1087314, rs2057482), and HO-1 (rs2071746) could alter susceptibility to perimenopausal CAD in this Chinese population.
The primary aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within two genes implicated in neuroplasticity and inflammatory processes (the mitogen activated protein kinase 1, MAPK1 (rs3810608, rs6928, rs13515 and rs8136867), and the cyclic AMP responsive element binding protein 1, CREB1 (rs889895, rs6740584, rs2551922 and rs2254137)) was associated with antidepressant treatment resistance (according to two different definitions), in 285 Major Depressive Disorder (MDD) patients.
Logistic regression analysis demonstrated that <i>MEK1</i> rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], <i>P</i> = 0.012), <i>ERK2</i> rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], <i>P</i> = 0.040) and <i>ERK2</i> rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], <i>P</i> = 0.002) were associated with PCOS risk without adjusting for age and body mass index.
Logistic regression analysis demonstrated that <i>MEK1</i> rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], <i>P</i> = 0.012), <i>ERK2</i> rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], <i>P</i> = 0.040) and <i>ERK2</i> rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], <i>P</i> = 0.002) were associated with PCOS risk without adjusting for age and body mass index.